Synthesis ofo-(2-Indolyl)benzoic Acids from Indole
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چکیده
منابع مشابه
Synthesis of Indole-Derived Fluorine-Containing Amino Acids
A Brønsted acid promoted direct aminoalkylation of various indoles with trifluoromethyl oxazolidine is described. A catalytic amount of triflic acid provided straightforward access to the corresponding trifluoromethyled amino esters under mild reaction conditions and a short reaction time of 4 h. On further hydrogenolysis and hydrolysis of ester, the synthesis of indole derived unnatural triflu...
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Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH gives oxazolines.
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Nencki and Sieber (1) first reported the formation of a red pigment in urine which had been made strongly acid by the addition of mineral acids, and they named the pigment “urorosein.” At one time considerable import was attached to the appearance of a strongly positive urorosein reaction (2, 3). Herter (2), however, established that this reaction frequently could be associated with gastrointes...
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A novel method for indole skeleton synthesis under mild conditions mediated by samarium(ii) diiodide has been developed. The reaction of N-allenyl-2-iodoaniline derivatives with SmI2 in the presence of HMPA and i-PrOH at 0 °C afforded indole derivatives in high yields.
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In the title indole derivative, C16H10BrCl2NO, the dihedral angle between the mean plane of the indole ring system and the mean plane of the disordered 2-bromo-phenyl ring is 77.6 (1)°. The non-H atoms of the chloracetyl group are essentially coplanar with the indole core. In the crystal, pairs of mol-ecules are face-to-face embraced via two weak C-H⋯O hydrogen bonds, forming inversion dimers w...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1981
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.54.305